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Clopidogrel is a prodrugInhibition of platelet aggregation by clopidogrel is achieved through an active metaboliteThe metabolism of clopidogrel to its active metabolite can be impaired by genetic variations in CYP2C19see BOXED WARNING

Clopidogrel is metabolized to its active metabolite in part by CYP2C19Concomitant use of certain inhibitors of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition.

Take Plavix exactly as your doctor tells youDo not change your dose or stop taking Plavix without talking to your doctor firstStopping Plavix may increase your risk of heart attack or strokeTake Plavix with aspirin as instructed by your doctorIf you miss a dosetake Plavix as soon as you rememberIf it is almost time for your next doseskip the missed doseTake the next dose at your regular timeDo not take 2 doses of Plavix at the same time unless your doctor tells you toIf you take too much Plavixcall your doctor or go to the nearest emergency room right awayTalk with your doctor about stopping your Plavix before you have surgeryYour doctor may tell you to stop taking Plavix at least 5 days before you have surgery to avoid excessive bleeding during surgery.

Take Plavix exactly as prescribed by your doctorFollow all directions on your prescription label and read all medication guides or instruction sheetsUse these medicines exactly as directed.

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